YU YAN

  Professor

  Department of Animal Sciences

  Phone: 34205833

  Email: yanyu@sjtu.edu.cn

  Address: Agri-building 3-405

 

 

 

Research Interests: Key Regulators of Tissue Regeneration and Drug Development

 

Education:

Biography: Dr. Yu received her BS degree in Biology from East China Normal University in 1985, and Ph.D. degree in Biomedical Sciences from Mount Sinai School of Medicine at CUNY in 1996. After completing post-doctoral training at Cornell Weill Medical College, she worked for OriGene Technologies Inc. for several years as a research Scientist. In mid-2004, Dr. Yu took a faculty position at Shanghai Jiao Tong University School of Agriculture and Biology of Professor in Animal Sciences, and joint professor at Shanghai Municipality Key Laboratory for Veterinary Biotechnology and National Key Laboratory for Oncogenes and Related Genes. During 2005-2015 she served as Assistant/Associate Dean of the school for International Affairs and Laboratory Management.

 

 

Research Experience/Achievement:

Trained in Dr. Leslie Pick’s lab as Ph.D. student working on transcriptional regulation of Drosophila early development, established a modified version of the Yeast Two Hybrid System to identify co-regulators of gene expression. During post-doc she studied the co-linearity regulation of the Hox gene family in mouse early development, and received two post-doc fellowships from NIH and ACS (American Cancer Society). She later joined a biotech company in Maryland specializing in Human Full-length gene cloning and identification. In August 2004, Dr. Yu returned to homeland and started her own lab in the School of Agriculture and Biology at SJTU. Since then her research has been focusing on the identification and characterization of key regulators for tissue damage and repair of multiple origins or by different causes, e.g. liver, cartilage, or chemotherapy-induced gastrointestinal side effect (CID), and the goal was to investigate the potential application of these key regulators in clinical usage. Over the years, Dr. Yu has published more than 50 peer-reviewed research papers and awarded with several Chinese national patents. Her main research was supported by grants from Chinese MOST, NSFC, Shanghai STCSM, and industry.

 

 

Publications (selected)

1.       Guan W, Yu XL, Li JJ, Deng Q, Zhang Y, Gao J, Xia P, Yuan YS, Gao J, Zhou L, Han W, Yu Y. Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice. Experimental and Therapeutic Medicine 2017,14(2):1001-1008

2.       Xia P, Gao J, Guan W, Li JJ, Yu XL, Wang FY, He HL, Deng Q, Zhou L, Yuan YS, Han W, Yu Y. Production of bioactive recombinant rat soluble receptor for advanced glycation end products (rrsRAGE) in Pichia Pastoris. Protein Expression and Purification, 2017,138:81-87

3.       Xia P, Deng Q, Gao J, Yu XL, Zhang Y, Li JJ, Guan W, Hu JJ, Tan Q, Zhou L, Han W, Y. Yuan YS, Yu Y. Therapeutic effects of antigen affinity-purified polyclonal anti-receptor of advanced glycation end-products(anti-RAGE) antibodies on cholestasis-induced liver injury in rats. European Journal of Pharmacology, 2016 779:102-110

4.       Zhang Y, Gao J, Wang X, Deng S, Ye H, Guan W, Wu M, Zhu S, Yu Y & Han W. CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity. Cancer Biol Ther. 2015 16(12):1775-83

5.       Gao J, Wu M, Gao J, Wang X, Zhang Y, Zhu S, Yu Y, Han W. Generation and characterization of a new monoclonal antibody against CXCL4. Monoclon Antib Immunodiagn Immunother. 2015 34(2):110-5

6.       Gao J, Li J, Yang M, Wu M, Tu P, Yu Y & Han W. Development of a cell based qualitative assay for detection of neutralizing anti-human interleukin 1 receptor antagonist (hIL-1Ra) antibodies in rats. Immunopharmacol Immunotoxicol. 2015 37(4):335-42

7.       Guan W, Deng Q, Yu XL, Yuan YS, Gao J, Li JJ, Zhou L, Xia P, Han GY, Han W, Yu Y. Blockade of S100A3 activity inhibits murine hair growth. Genet Mol Res. 2015 14(4):13532-44

8.       Wang X, Gao J, Qian L, Gao J, Zhu S, Wu M, Zhang Y, Guan W, Ye H, Yu Y & Han W. Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis. Anticancer Drugs. 2015 26(1):35-45

9.       Xu C, Zhu S, Wu M, Zhao Y, Han W, Yu Y. The Therapeutic Effect of rhMK on Osteoarthritis in Mice, Induced by Destabilization of the Medial Meniscus. Biol Pharm Bull. 2014 37(11):1803-10

10.   Yuan Y. Zhang X. Weng S. Guan W. Xiang D. Gao J. Li J. Han W. Yu Y. Expression and purification of bioactive high-purity recombinant mouse SPP1 in Escherichia coli. Applied Biochemistry and Biotechnology 2014 173(2):421-32

11.   Xu C, Zhu S, Wu M, Han W, Yu Y. Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN). Biol Pharm Bull. 2014 37(4):511-20

12.   Gao J, Jin G, Qian L, Wang X, Wu MY, Zhang Y, Zhu SY, Yu Y & Han W. Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluouracil. Cancer Biology & Therapy 2014 15(8):1-10

13.   Wang X, Zhu SY, Qian L, Gao J, Wu MY, Jin G, Zhang Y, Chan GL, Yu Y & Han W. IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21WAF1 and p27KIP1. Pharmacological Research 2014 82:21-33

14.   Hartman MR, Ruiz R, Hamada S, Xu CY, Yancey KG, Yu Y, Han W, and Luo D. Point‐of‐care nucleic acid detection using nanotechnology. Nanoscale, 2013 5:10141-10154

15.   Zhao M, Gao J, Zhu S, Qian L, Wang X, Gao J, Zhang Y, Yu Y, Han W, Wu M. Characterization of activin A in the culture of primitive human umbilical cord blood hematopoietic cells. Biomed Pharmacother. 2012 66(8):603-606

16.   He H, Han L, Guan W, Li J, Han W, Yu Y. An efficient expression and purification strategy for the production of S100 proteins in Escherichia coli. Bioengineered. 2013 4(1):55-58

17.   He H, Yang T, Jia S, Zhang R, Tu P, Gao J, Yuan Y, Han W, Yu Y. Expression and purification of bioactive high-purity human S100A6 in Escherichia coli. Protein Expression and Purification. 2012 83(1):98-103

18.   Lu H, Zhu S, Qian L, Xiang D , Zhang W, Nie A, Gao J, Wu M, Gao J, Lu B, Yu Y & Han W, Moldenhauer A. Activated expression of the chemokine Mig following chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity. Blood. 2012 119(21):4868-4877

19.   Li JJ, Gao J, Sah S, Satyal U, Zhang R, Han W, Yu Y. Expression and Purification of Bioactive High-Purity Recombinant Mouse CXCL14 in Escherichia coli. Appl Biochem Biotechnol 2011 164:1366-1375

20.   Xu CY, Zhang Y. Wu MY, Zhu SY, Gao J, Zhang J, Yuan YS, Zhang K, Yu Y & Han W. Recombinant human midkine stimulates proliferation and decreases dedifferentiation of auricular chondrocytes in vitro. Experimental Biology and Medicine 2011 236:1254-1262

21.   Li JJ, Gao J, Yan D, Yuan YS, Sah S, Satyal U, Liu M, Han W, Yu Y. Neutralization of chemokine CXCL14 (BRAK) expression reduces CCl4 induced liver injury and steatosis in mice. European Journal of Pharmacology 2011 671:120-127

22.   Xiang D, Guo YP, Zhang J, Zhu SY, Lu HL, Wu MY, Yu Y & Han W. Interleukin 1 receptor antagonist attenuates cyclophosphamide-induced mucositis in a murine model. Cancer Chemotherapy and Pharmacology 2011 67:1445-53

23.   Xie C, Gao J, Zhu RZ, Yuan YS, He HL, Huang QS, Han W, Yu Y. Protein-protein interaction map is a key gateway into liver regeneration. World J Gastroenterol. 2010 16(28):3491-8

24.   Hu JJ, Yan DJ, Gao J, Xu CY, Yuan YS, Zhu RZ, Xiang D, Weng SY, Han W, Zang GQ & Yu Y. rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure. Laboratory Investigation 2010 90:1737-1746

25.   Zhu RZ, Xiang D, Xie C, Li JJ, Hu JJ, He HL, Yuan YS, Gao J, Han W, Yu Y. Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice. World Journal of Gastroenterology 2010 16(22):2771-9

26.   Zhang ZH, Li HX, Qi Y, Lijuan Du LJ, Zhu SY, Wu MY, HL, Yu Y & Han W. Recombinant human midkine stimulates proliferation of articular chondrocytes. Cell Prolif. 2010 43:184–194

27.   Zheng ZY, Weng SY, Yu Y. Signal molecule-mediated hepatic cell communication during liver regeneration. World J Gastroenterol, 2009 15:5776-5783

28.   He HL, Li JJ, Weng SY, Li MF and Yu Y. S100A11: Diverse function and pathology corresponding to different target proteins. Cell Biochem Biophys 2009 55:117-126

29.   Yuan Y, Wu X, Ou Q, Gao J, Tennant BC, Han W, Yu Y. Differential expression of the genes involved in amino acids and nitrogen metabolisms during liver regeneration of mice. Hepatol Res. 2009 39 (3):301-12

30.   Gao J, Li WX, Feng SQ, Yuan YS, Wan DF, Han W, Yu Y. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Genomics. 2008 91 (4):347-55

31.   Han W, Yu Y & Liu XY. Local signals in stem cell-based bone marrow regeneration. Cell Research, 2006 16:189-195

32.   Leslie Pick, U Lohr, Yu Y A Double Interaction Screen to isolate DNA binding and protein tethered transcription factor. In: Yeast hybrid techniques - Genetic assay system for protein interaction. Zhu L and Hannon GJ. 2000 Natick. MA: Eaton Publishing

33.   Yu Y, Yussa M, Song JB, Hirsch J, and Pick L. A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins. Mech. Dev., 1999 83: 95-105

34.   Yu Y, Li W, Su K, Yussa M, Han W, Perrimon N, and Pick L. The nuclear hormone receptor FTZ-F1 is a cofactor for the Drosophila homeodomain protein fushi tarazu. Nature, 1997 385: 552-555