TIME ：12:40-14:00 July 14, 2021 (Wednesday)

VENUE：Room 104, Building B, School of Agriculture and Biology

ORGANIZER：Office of Discipline and Science & Technology, SAB; Young Teachers Association, SAB

TITTLE: Unique innate immunity strategies against avian influenza virus in chickens

ABSTRACT: 

Chickens are highly susceptible to highly pathogenic avian influenza virus (AIV) and show a high mortality after AIV infection, and they act as the cross host vectors of AIV to infect humans. According to the traditional theory, "the natural missing of innate immune genes, such as RIG-I and IRF3, leads to severe immune deficiency in chickens, which is the key reason for the susceptibility and high mortality of chickens to AIV." The reporter's group found that although the capacity of chicken innate immune genes is smaller than that of mammals, and they lacks many key innate immune molecules, they employ a series of strategies to form an unique innate immune defense networks to participate in anti-AIV immune response. Combined with other reports, the reporter concluded that the innate immune system of chickens is not inferior. In actually, chickens have a stronger innate immune response, and the over activation of innate immunity by the infection of AIV may be the real cause of its high mortality to AIV.